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Abstract The successful development and implementation of precision immuno-oncology therapies requires a deeper understanding of the immune architecture at a patient level. T-cell receptor (TCR) repertoire sequencing is a relatively new technology that enables monitoring of T-cells, a subset of immune cells that play a central role in modulating immune response. These immunologic relationships are complex and are governed by various distributional aspects of an individual patient's tumor profile. We propose Bayesian QUANTIle regression for hierarchical COvariates (QUANTICO) that allows simultaneous modeling of hierarchical relationships between multilevel covariates, conducts explicit variable selection, estimates quantile and patient-specific coefficient effects, to induce individualized inference. We show QUANTICO outperforms existing approaches in multiple simulation scenarios. We demonstrate the utility of QUANTICO to investigate the effect of TCR variables on immune response in a cohort of lung cancer patients. At population level, our analyses reveal the mechanistic role of T-cell proportion on the immune cell abundance, with tumor mutation burden as an important factor modulating this relationship. At a patient level, we find several outlier patients based on their quantile-specific coefficient functions, who have higher mutational rates and different smoking history. 

Human decision making is plagued by systematic errors that can have devastating consequences. Previous research has found that such errors can be partly prevented by teaching people decision strategies that would allow them to make better choices in specific situations. Three bottlenecks of this approach are our limited knowledge of effective decision strategies, the limited transfer of learning beyond the trained task, and the challenge of efficiently teaching good decision strategies to a large number of people. We introduce a general approach to solving these problems that leverages artificial intelligence to discover and teach optimal decision strategies. As a proof of concept, we developed an intelligent tutor that teaches people the automatically discovered optimal heuristic for environments where immediate rewards do not predict long-term outcomes. We found that practice with our intelligent tutor was more effective than conventional approaches to improving human decision making. The benefits of training with our cognitive tutor transferred to a more challenging task and were retained over time. Our general approach to improving human decision making by developing intelligent tutors also proved successful for another environment with a very different reward structure. These findings suggest that leveraging artificial intelligence to discover and teach optimal cognitive strategies is a promising approach to improving human judgment and decision making.